PROGRAM SCIENTIST 2, IMMUNOLOGY, Biological Engineering (BE), to help launch and expand a major new program in Engineering Women’s Health; assist in coordinating several interdisciplinary, multi-investigator projects centered on developing, implementing, and broadly disseminating new immunological assays that capture features of human pathophysiology; facilitate the day-to-day collaboration of the immunological and computational tool development teams with the engineering and clinical teams; and assist in strategic planning for creating a core facility, preparing grants and reports, technical content, and organizing contributions from other team members, among other tasks.

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PROGRAM SCIENTIST 2, ENGINEERING, Biological Engineering (BE), to help launch and expand a major new program in Engineering Women’s Health; assist the PIs in coordinating several interdisciplinary, multi-investigator projects centered on developing new microfluidic imaging, biomaterials, tissue engineering, and sensing technologies that capture features of human pathophysiology; facilitate the day-to-day collaboration of the engineering and computational tool development teams with basic biology; assist immunology and clinical teams in defining design criteria for “Novel Alternative Methods (NAMs)” for generating humanized experimental data; and assist in strategic planning for the creation of a core facility accessible to other researchers and pilot projects demonstrating feasibility.

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POSTDOCTORAL ASSOCIATE, Biological Engineering (BE), to work on a project that involves studies of interactions among different DNA repair activities and how these interactions shape the biological consequences of exposure to DNA damage. Will perform mouse husbandry for multiple mouse strains; develop methods to visualize clonally expanded cells using 2-photon microscopy in collaboration with TissueVision; handle and treat mice with N-nitrosadimethylamine; perform spatial transcriptomics; study mutagenesis and carcinogenesis; and prepare figures and drafts of manuscripts.

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TECHNICAL ASSOCIATE II, Biological Engineering-Tal Group, to research comparative predictive diagnostics for infection-associated chronic illnesses (viral, bacterial, and fungal pathogens) through deep immunoinflammatory profiling.  Will investigate antibody levels and ratiometric scores against key pathogen classes that may drive symptoms after infection; optimize flow-based immunoprofiling (FLIP) analysis for different pathogen targets and analyze antibody results; optimize, execute, and analyze/interpret high-resolution flow cytometry assays; perform Luminex antibody assays and analyze/interpret data; and culture Borrelia burgdorferi and execute in vitro experiments as needed.  There will be occasional biobanking of clinical study participant samples and assisting with clinical study participant visits.

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RESEARCH SCIENTIST 2, Biological Engineering-Synthetic Biology Center-Weiss Lab, to join an interdisciplinary research lab seeking to create integrated biological systems capable of autonomously performing tasks related to the activities of therapeutic agents for a variety of applications, including immunotherapy.  Will participate in government- and corporate-sponsored research in mammalian synthetic biology, including genetically encoded therapies that perform cell type classification and conditionally administer appropriate therapeutic molecules.  These mammalian genetic circuits will sense cell state, including miRNA levels, and implement multi-input logic regulating the expression of proinflammatory cytokines. Genetic circuits will be encoded on RNA replicons and distinguish between cell types such as lung cancer and T cells. Cell type identification will be based on determining an optimal combination of low and high miRNAs present or absent in the relevant cell types. Another level of control will be based on externally-administered small molecules that modulate the stability of regulatory RNA binding proteins. Will also engineer subgenomic promoters of RNA replicons for optimized tandem expression of constitutive and small molecule-regulated payloads in cancer and immune cells. 

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TECHNICAL ASSOCIATE I, Biological Engineering, to provide technical assistance on multiple high-impact projects in the research lab of Professor Katharina Ribbeck. These include the isolation and purification of mucus components for the development of assays to identify artificial sweeteners with superior flavor properties, the development of chemical profiling methods to identify properties of salivary mucus that mediate favorable sweetener perception, and the development of mucus-based assays to predict sweetener perception. Primary responsibilities will include developing and implementing biochemical protocols for mucin isolation from saliva, isolating and characterizing mucin-associated glycans, testing sweetener function in the context of mucus, and other tasks as assigned. 

Description, requirements, and details on MIT HR Job Openings

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