Seminars

Metastatic tumors to bone induce local degradation, resulting in painful pathological fractures and reduced tumor removal options. Here, we develop a combination treatment where alongside photothermal ablation, thermally-responsive intratumoral microparticle depots control release of bone-strengthening drugs. We validate the platform in a subcutaneous mammary tumor model and then demonstrate local delivery within the bone environment. This leads to current work in reducing tumor burden while recovering bone density in a bone metastasis model.

The attachment of particular glycan structures to the Fc region of IgG is a critical determinant of antibody-mediated immune activity, with important consequences for autoimmunity, infection, and cancer. Although the enzymatic steps involved in this post-translational modification are well-characterized, the intracellular regulatory processes governing these glycan structures are not understood. Here, we combine transcriptomics and glycomics to probe how human B cells translate extracellular inflammatory signals into an IgG-specific response.