Seminars | MIT Department of Biological Engineering

Start Time: 12:00PM

Location: 32-155

Hosted By: Bevin P. Engelward

Mead Lockwood

Collins Lab

Ulcerative colitis is a chronic autoimmune disease of the colonic epithelium that substantially impacts patient quality of life. Biologic therapies have revolutionized the treatment of ulcerative colitis, however their systemic delivery can lead to serious adverse effects that constrain their overall utility. Here, we detail our work to engineer the probiotic yeast Saccharomyces boulardii as an enterically targeted living therapeutic for ulcerative colitis that enables localized delivery of biologic therapies to active sites of disease.
Nickeisha Cuthbert

Niles Lab

Plasmodium falciparum is the deadliest cause of human malaria. Although front-line antimalarials like
artemisinin (ART) have significantly reduced the malaria burden, cases of P. falciparum parasites that survive ART exposure are increasing. Dysregulation of the Pfkelch13 gene is implicated in ART resistance, though its precise function within the parasite remains unclear. We utilized a conditional knockdown (cKD) system in an assay designed to modulate Pfkelch13 expression and assess the effect on P. falciparum survival and resistance to ART.

All Seminars

Start Time: 4:00PM

Hosted By: Domitilla Del Vecchio

Richard M. Murray

California Institute of Technology

Upscaling Engineering of Synthetic Biomachines via Synthetic Cells