Antibiotics in Lyme Arthritis: A Humoral Immune Modeling Approach to Dissecting Outcomes
Arthritis occurs in roughly 30% of people infected with Lyme disease but typically resolves with antibiotic treatment. However, some Lyme arthritis cases are refractory to antibiotics. To better understand differences between outcomes, we utilized computational approaches to model humoral immune response in antibiotic-responsive and antibiotic-refractory patients for both serum and joint fluid. Here, we present fluid-specific humoral profiles distinct to each patient group.