Effects of Probiotics on DNA Damage-Induced Cancer and Mutations
Exposure to DNA damaging agents substantially increases the risk of cancer by inducing potentially carcinogenic mutations. Probiotics have been demonstrated to suppress tumorigenesis in animals predisposed to cancer. While there are in vitro studies suggesting that probiotics may suppress mutations and genotoxicity, there are few studies that examine these properties in vivo. We have used two mouse models to examine the impact of probiotics on mutations and cancer induced by a DNA damaging agent under various exposure paradigms.