Probing Mucins as Host-derived Immunomodulators of Neutrophils
Mucus is a hydrogel that coats >2000 ft2 of human surfaces not covered by skin. In addition to constant exposure to exogeneous agents, mucus also houses the microbiome, providing various potential sources of inflammation. However, how the immune system tolerates the abundance of immunostimulatory factors without excessive inflammation remains unclear. Here, we demonstrate that mucins, the main proteins in mucus, are potent host-derived immunomodulators of neutrophil activation, revealing a potential mechanism underlying mucosal homeostasis.