Speaker:
Title:
Methods to Isolate Tumor-Specific Antibodies Induced by Immunotherapy
Abstract:
Combination immunotherapy has been shown to potently eliminate
tumors and induce immunological memory in mouse models. Mice that are cured
by this therapy develop endogenous antibodies that are protective against the
tumor. Interestingly, endogenous antibodies found in a subset of these mice
show specificity toward other tumor cells, suggesting the possible existence
of shared antigens. To better understand the specificity of these antibodies,
this work explores different approaches to isolating tumor-specific
antibodies from mouse organs.