Elucidating the Surface Proteome of Mycobacterium tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a leading cause of infectious disease death. Current vaccine candidates fail to protect adults from pulmonary TB. Determining which antigen(s) to include in vaccines is a challenge magnified by a partial picture of host accessible proteins. Here, we adapt a protein shaving protocol to identify proteins from the Mtb surface proteome and characterize protein hits to better inform our understanding of Mtb surfaceome composition and expand the pool of potential vaccine antigens.