Speaker:
Title:
A Dynamics-based Approach Toward Redesigning a Natural Enzyme
Abstract:
Enzymes represent some of the most efficient and precise catalysts in the world, with applications ranging from therapeutics to manufacturing. However, our limited ability to rationally tune and tailor enzyme activity to specific substrates has restricted their applicability, efficiency, and cost effectiveness. Here, we present computational methods that illuminate enzyme catalysis with atomistic detail, providing new insights that we leverage to guide enzyme redesign.
