Speaker:
Title:
Characterizing Treatment-induced Immunopeptidomic Shifts in Glioblastoma
Abstract:
Glioblastoma treatment has not seen a breakthrough in over 20 years, but recent studies suggest that with an optimization of timing and context, GBM could be responsive to immunotherapies. To guide this optimization, I characterized how radiation induces rapid remodeling of the immunopeptidome and its relationship to DNA damage signaling networks. These findings could inform the design of combination therapies that improve GBM’s response to immunotherapy.