Interrogating Macrophage States in Tuberculosis
Tuberculosis presents heterogeneous clinical and pathological outcomes. Understanding the cellular correlates of the disease spectrum remains a central goal to develop a broadly effective vaccine. Macrophages perform primary roles during pathogenesis, such as harboring bacteria and recruiting lymphoid cells. In this talk, we discuss macrophage cell states associated with active granulomas and successful vaccination in macaque models. Furthermore, we present preliminary efforts to understand cytokine signals driving these states.