Elucidating the Human Disease Relevance of Alzheimer’s Disease Mouse Models
While amyloid and tau pathology are defining characteristics of Alzheimer’s Disease (AD), they do not robustly correlate with disease severity. Nonetheless, amyloid and tau dysregulation are key features in most AD mouse models. To address this limitation, we developed a computational framework for translation of molecular/phenotype relationships. In this talk, I will discuss case studies using individual AD mouse models and our efforts to identify consensus, human AD-relevant transcriptomic signatures at the intersection of multiple models.