Combining Whole-cell and Subunit Approaches for a New Malaria Vaccine
Current malaria vaccines utilize either subunit or whole-cell approaches and are inefficient in offering protection. I propose a combined approach wherein a whole parasite serves as a chassis for protein presentation to reap the benefits of specific, chosen antigens on a non-specified protein-presenting surface of the parasite membrane. Parasite lines were generated with conditional expression of protein fusions for a vaccine prototype. This should protect across the parasite life cycle to combat infection, growth, and transmission.