Characterization of Macrophage Heterogeneity in Tuberculosis Granulomas
Macrophages polarize to distinct phenotypes based on functional demands of their environment. The balance of these immune states has been implicated in the formation of granulomas and the progression of tuberculosis. However, the landscape of these phenotypes in tuberculosis remains ill-defined. In this talk, we define transcriptional macrophage states found within tuberculosis granulomas by utilizing single-cell RNA-sequencing data.