Development of a Genetically Encoded Potassium Sensor for Visualizing Neuron Activity
In neuroscience, genetically encoded sensors have proven useful to study neuron activity in different contexts. Yet, current sensors are unable to detect single spiking activity in large neuron populations. Potassium ions can be good indicators of this activity because of their role in membrane excitability; however, there are no good, non-invasive ways to measure this ion’s dynamics. Here, we propose that genetically encoded potassium sensors can be optimized to detect such activity in dense neural circuits.