Speaker:
Title:
An Interpretable Model of Cell Type-specific Chromatin Accessibility
Abstract:
Chromatin structure plays fundamental roles in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA damage repair. Despite its importance, the sequence motifs that determine cell type-specific chromatin accessibility are still poorly understood. We aim to identify human-interpretable cell type-specific rules of chromatin accessibility using neural network based classifiers trained on DNase-seq and ATAC-seq data, and present a way to experimentally validate these in silico derived rules.