Development of Repertoire-scale Methods to Decode Immune Recognition
T cells use their antigen receptors to defend against pathogens and retain “memory” of the attack to bolster the immune defense against subsequent exposures. Understanding this recognition event remains a key unmet challenge in immunology. Current techniques used to determine their antigen specificity remain laborious and are limited to studying, at best, a handful of the millions of unique T cells found in a single person. Here, I discuss the development of a high-throughput assay to determine T cell recognition at repertoire scale.