BATS

Date/Time:

May 11, 2018 - 12:00 PM

Location:

Hosts:

Bevin Engelward

Speaker:

Title:

Engineering Single Domain Antibody-based CAR T Cells for the Treatment of Solid Tumors

Abstract:

Chimeric antigen receptor (CAR) T cells are a promising cancer therapeutic, as they can specifically redirect the cytotoxic function of a T cell to a chosen target of interest. CAR T cells have been successful in clinical trials against hematological cancers, but have experienced low efficacy against solid tumors for a number of reasons, including a lack of tumor specific antigens. To treat solid tumors, we aim to develop CARs utilizing single domain antibody fragments (VHHs) that target various aspects of the tumor microenvironment.

Speaker:

Title:

Gastric Resident Devices for Large Dose Drug Delivery

Abstract:

Medication nonadherence is an enormous global problem and contributes to prolonged infectiousness and death. I will present novel gastric resident devices for controlled release drug delivery to simplify treatment regimens and thereby prevent the development of drug resistance arising from nonadherence. These systems offer multiple advantages over currently available injectable depot formulations, including ease of administration, lack of immunologic reactions limiting drug release, and the ability to accommodate gram-level dosing.