Discovery and Characterization of an Epigenomic Signature of Late-stage Cellular Differentiation
Epigenetic markers, such as histone modifications, are linked to the regulation of DNA organization and help define gene expression programs. We have found that a signature of cellular differentiation across multiple cell type groups is the decreasing abundance of regions marked by a particular combination of histone modifications (H3K9me3 and H3K36me3). The location of these changing regions varies by cell type group. I will discuss what we have learned about which regions are likely to change and the effect of these epigenetic changes.