Ally Huang (SASISEKHARAN LAB)

A Novel Platform for the Engineering of Bispecific Antibodies Using Structure-based Design

Bispecific antibodies allow for promising new targeting strategies in cancer, especially for resistance and immunotherapy, but current design processes requires each individual bispecific combination to be uniquely engineered. To address this bottleneck in design, we aim to use computational structure-based protein design tools to develop a bispecific platform process that is portable and applicable to the design of all bispecific combinations. My talk will focus on the development and validation of this more efficient bispecific platform.

Tzu-Chieh Tang (LU & OXMAN LABS)

Tough Hydrogel-based Capsules for Deployment of Engineered Organisms

Biosafety has become a major challenge for synthetic biology tools to transition from laboratory experiments to real applications. We developed an encapsulation technique by leveraging a tough hydrogel shell and genetically recoded organisms to achieve unprecedented containment performance. This approach enables convenient sample retrieval, controlled lifespan, and protection against insults. We demonstrated that the encapsulated cells can sense, respond, and record environmental inputs in a real-world setting such as in Charles River water.