Engineering Physiologically Relevant In Vitro Liver Models
The liver is responsible for a variety of metabolic, homeostatic, and immunologic activities in the body. As such, in vitro liver models are finding increasing use in applications of modeling disease and complex drug metabolism. To create more sophisticated and physiologically relevant liver models, fundamental design principles still need to be revealed. In this work, I consider the morphological steps of in vitro liver tissue formation, as well as strategies going forward to provide the necessary external cues for improved functionality.