ERK Mediated Phosphorylation and Stabilization of ZEB1 is Necessary for EMT Induction
Epithelial to mesenchymal transition (EMT) has been shown to play a critical role in regulating cancer metastasis and emergence of drug resistant tumor cells. In this study we have investigated changes in dynamic signaling networks during ZEB1 induced EMT to identify potential therapeutic targets to inhibit EMT. Here, we show that SRC family kinases are essential for EMT induction. We have also identified three novel ERK mediated phosphorylation sites on ZEB1, the master regulator of EMT, that are indispensable for ZEB1 stability.