Speaker:
Title:
Image-based Temporal Modeling of Morphology Dynamics for Profiling Live-Cell Phenotypes
Abstract:
As the use of live-cell imaging continues to grow, new tools are needed to objectively characterize, compare, and classify dynamic cellular responses to external perturbations. I will present a framework that combines live imaging, image processing and analysis, and temporal modeling, to characterize cell shape dynamics from high-content time series imaging data. This framework can be used as a phenotypic drug profiling tool and enables hypothesis generation for mechanistic follow-up studies.