Targeted Perturbations Expand Ecosystem Function in the Mammalian Gut Microbiota
Animal guts harbor the densest microbial ecosystems on the planet, and these ecosystems orchestrate the health of their host. Disruptions of this ecosystem following pathogen infection lead to remodeling of this community. The only microbial therapy in such cases, fecal microbiota transplant, remains ill-defined and difficult to regulate. Here, I demonstrate a targeted approach to remodeling ecosystems in healthy individuals. This work offers a route for development of defined microbial therapeutics in a range of clinical indications.