Understanding T Cell Diversity in Peanut Allergy
Peanut allergy is a type 1 hypersensitivity condition driven by a combination of T cells and B cells. Oral immunotherapy (OIT) is a promising treatment for peanut allergy, but long-term clinical outcomes have been variable, and the cellular mechanism of the therapy is still debated. Here, we propose using T cell receptor sequencing to characterize the dynamics of T cell repertoires in patients undergoing peanut OIT. In particular, we seek to understand the importance of T cell clonal responses in peanut OIT.