Liposome-Based MRI Contrast Agents; A Modular Architecture for Neurotransmitter Sensors
High-Field MRI allows for repeated non-invasive whole brain imaging which is not possible using traditional approaches. We have demonstrated the ability to observe molecular-level events with fMRI by employing sensors for molecules involved in neural signaling. Molecular fMRI has the potential to be a revolutionary technique for the study of neural circuits with long-term implications for human health. I present a novel MRI contrast mechanism, predicted to give large signal changes, that utilizes liposomes as ligand-gated water proton barriers.