BATS

Date/Time: 

Dec 7, 2018 - 12:00 PM EST

Title: 

Characterizing Signaling Dynamics in Response to Environmental Pollutants

Abstract: 

Increased exposure to contaminants like polycyclic aromatic hydrocarbons (PAHs) have put people at a higher risk of developing chronic complications. Despite decades of research, pathways underlying the cellular response to these contaminants are still poorly understood. This work aims to apply a systems biology approach to elucidate the molecular and cellular response to PAHs at physiologically relevant dose and time regimens. Here, we quantify tyrosine phosphorylation signaling and DNA damage response pathways at the systems level.

Title: 

Constructing a Site-specific Kinetic Model of the EGFR Signaling Network

Abstract: 

EGFR signals through a complex cellular network and its aberrant signaling and expression have been linked to many diseases. Efforts made to increase the understanding of the signaling dynamics of EGFR to design novel therapies and improve clinical outcome have led to the construction of several models. However, these models lack critical aspects that affect their prediction accuracy. This work aims to develop a predictive quantitative and site-specific model reflecting the topology and temporal dynamics of the EGFR network in mammalian cells.