BATS

Date/Time: 

Nov 30, 2018 - 12:00 PM EST

Title: 

Development of Repertoire-scale Methods to Decode Immune Recognition

Abstract: 

T cells use their antigen receptors to defend against pathogens and retain “memory” of the attack to bolster the immune defense against subsequent exposures. Understanding this recognition event remains a key unmet challenge in immunology. Current techniques used to determine their antigen specificity remain laborious and are limited to studying, at best, a handful of the millions of unique T cells found in a single person. Here, I discuss the development of a high-throughput assay to determine T cell recognition at repertoire scale.

Title: 

Analysis of Alzheimer’s Disease-relevant Cell Signaling and Communication

Abstract: 

Amyloid beta (Aß) is a known and characteristic trigger of Alzheimer’s Disease (AD). However, univariate Aß hypotheses are insufficient to explain AD progression; increasing evidence implicates dysregulated neuron-glia interactions in response to Aß accumulation. This work aims to identify innate immune system molecular mechanisms affecting neuron cell signaling and associated phenotypic response to Aß. This talk focuses on computational inference of AD-relevant signaling pathway activity and neuron-glia communication using transcriptomic data.